BX471 hydrochloride

Research use only, not for human use.

BX471 is a potent, selective, orally available CCR1 antagonist with Ki of 1 nM for hCCR1, displays 100 times less affinity for rat CCR1.

BX471 is a potent, selective, orally available CCR1 antagonist with Ki of 1 nM for hCCR1, displays 100 times less affinity for rat CCR1; shows 10,000-fold selectivity for CCR1 compared with 28 GPCRs (); displays CCR1 ligands MIP-1α, RANTES, and MCP-3 with high affinity (Ki=1-5.5 nM), inhibits a number of CCR1-mediated effects including Ca(2+) mobilization, increase in extracellular acidification rate, CD11b expression; effectively reduces disease in a rat experimental allergic encephalomyelitis model of multiple sclerosis.Multiple Sclerosis Discontinued.

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BX-471 hydrochloride | BX 471 hydrochloride

GPCR/G Protein

Chemokine Receptor

Chemokine Receptor

Inflammation/Immunology

Multiple Sclerosis

288262-96-4

471.3526

C21H25Cl2FN4O3

>98% (HPLC)

10 mM in DMSO

CC1CN(CCN1C(=O)COC2=C(C=C(C=C2)Cl)NC(=O)N)CC3=CC=C(C=C3)F.Cl

Urea, N-[5-chloro-2-[2-[(2R)-4-[(4-fluorophenyl)methyl]-2-methyl-1-piperazinyl]-2-oxoethoxy]phenyl]-, hydrochloride (1:1)

(-20℃)

With Ice Pack

≥ 2 years